Polymorphisms ofIKBKEgene are associated with major depressive disorder and panic disorder

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منابع مشابه

Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder

BACKGROUND The immune system has been increasingly implicated in the development of mood and anxiety disorders. Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (IKBKE) gene encodes IKKε protein that is involved in innate immunity, predominantly antiviral response generation. It also bears pro-inflammatory properties that could affect psychiatric outcomes. In order ...

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Comorbidity of panic and major depressive disorder.

The objective of this report is to determine whether those patients with panic disorder who have current major depression disorder (MDD) differ from those who do not in terms of demographics, comorbid disorders, severity of illness, nature of symptoms of panic attacks and psychosocial functioning. The sample consisted of 182 patients with current or history of panic disorder measured by standar...

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Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population.

Major depressive disorder (MDD) and panic disorder (PD) are common and disabling medical disorders with stress and genetic components. Dysregulation of the stress response of the hypothalamic-pituitary-adrenal axis, including the corticotrophin-releasing hormone (CRH) signaling via primary receptors (CRHR1 and CRHR2), is considered to play a major role for onset and recurrence in MDD and PD. To...

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Aripiprazole-induced gray matter growth in a patient with major depressive disorder with panic disorder.

To the Editor: Aripiprazole, a D2 partial agonist antipsychotic, was recently approved by the US Food and Drug Administration for major depressive disorder (MDD) add-on therapy. Its effects are believed to be related to its 5-HT1A partial agonist, 5-HT2C antagonist, and 5-HT2A antagonist properties. Here, I present a case of MDD with panic disorder in which improvement of symptoms was seen afte...

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Heart rate variability in drug-naïve patients with panic disorder and major depressive disorder.

Power spectral analysis of electrocardiogram (ECG) R-R intervals is useful for the detection of autonomic dysfunction in various clinical disorders. Although both panic disorder (PD) and major depressive disorder (MDD) are known to have effects on the cardiac autonomic nervous system, no previous study has tested this among drug-naïve (i.e. no history of treatment) patients with MDD and PD in t...

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ژورنال

عنوان ژورنال: Brain and Behavior

سال: 2015

ISSN: 2162-3279

DOI: 10.1002/brb3.314